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Q J Med 2004; 97: 187-198
QJM vol. 97 no. 4 (c) Association of Physicians 2004; all rights reserved.

Review

Do we need additional markers of myocyte necrosis: the potential value of heart fatty-acid-binding protein

H.A. Alhadi and K.A.A. Fox

From the Cardiovascular Research Unit, Centre for Cardiovascular Science, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK

Heart fatty-acid-binding protein (FABP) is a small cytosolic protein that is abundant in the heart and has low concentrations in the blood and in tissues outside the heart. It appears in the blood as early as 1.5 h after onset of symptoms of infarction, peaks around 6 h and returns to baseline values in 24 h. These features of H-FABP make it an excellent potential candidate for the detection of acute myocardial infarction (AMI). We review the strengths and weaknesses of H-FABP as a clinically applicable marker of myocyte necrosis in the context of acute coronary syndromes.

Address correspondence to Professor K.A.A. Fox, Professor of Cardiology, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB. e-mail: k.a.a.fox{at}ed.ac.uk


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