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Q J Med 2000; 93: 207-215
© 2000 Association of Physicians

Review

Bartter syndrome: an overview

I. Amirlak and K.P. Dawson

From the Department of Paediatrics, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates

The term Bartter syndrome denotes a group of renal diseases which share a common denominator of hypokalaemia and metabolic alkalosis. The patch-clamp technique has made possible the analysis of single ion channels, improving our understanding of the molecular physiopathology of all the ‘Bartter-like’ syndromes. Genetic mapping of each defect has further clarified the mutations involved and the possible modes of inheritance. This improved understanding has opened new avenues for therapy, improving mortality and morbidity in these patients. Another group of illnesses, the ‘pseudo-Bartter syndrome’, may produce a hypokalaemic metabolic alkalosis without primary renal disease. The underlying illness needs to be identified and treated.

Address correspondence to Dr I. Amirlak, Department of Paediatrics, Faculty of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, United Arab Emirates. e-mail: iradj.amirlak{at}uaeu.ac.ae


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