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Q J Med 1999; 92: 309-318
© 1999 Association of Physicians

Familial Mediterranean fever in children: the expanded clinical profile

H.A. Majeed, M. Rawashdeh1, H. El-Shanti1, H. Qubain, N. Khuri-Bulos and H.M. Shahin

From the Department of Pediatrics, Faculty of Medicine, University of Jordan, and 1 Department of Pediatrics, Faculty of Medicine, Jordan University of Science and Technology, Jordan

Received 6 April 1999

Dr H.A. Majeed, PO Box 850 684, Suwaifiya 11185, Amman, Jordan. e-mail: pal{at}go.com.jo

The clinical picture of familial Mediterranean fever (FMF) has been appreciably expanded in the last 10 years. Over 8 years, we studied the expanded clinical profile of FMF in 476 children. Of these, 81% had abdominal pain, 41% chest pain, 42% arthritis, 12% severe myalgia, 12% skin manifestations, 4% scrotal swelling, 3% recurrent episodic fever, and one child (0.2%) developed recurrent hyperbilirubinaemia. Two (0.4%) children developed renal complications which were reversed by colchicine; however of 19 probands, 36 family members suffered from chronic renal failure. Our study indicates a familial predisposition to nephropathy in certain families with FMF. This study is the first to report the expanded clinical profile of FMF in a large group of Arab children, giving an opportunity to compare the findings with those in children with FMF in other ethnic groups, and to help in the study of genotype-phenotype correlation.


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