Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Reeve, J.
Right arrow Articles by Mitchell, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reeve, J.
Right arrow Articles by Mitchell, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Q J Med 1999; 92: 261-273
© 1999 Association of Physicians

Determinants of the first decade of bone loss after menopause at spine, hip and radius

J. Reeve, J. Walton, L.J. Russell, M. Lunt, R. Wolman, R. Abraham, J. Justice1, A. Nicholls2, B. Wardley-Smith, J.R. Green and A. Mitchell

From the University of Cambridge Department of Medicine, Northwick Park Hospital, 1 Eastcote Lane Practice, and 2 Pinn Medical Centre,Harrow, UK

Received 15 February 1999

Dr J. Reeve, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 2SR.e-mail:j.reeve{at}mrc-bsu.cam.ac.uk

This study documented bone loss at three different sites in the early postmenopausal period, and examined potential predictors. Forty-three women underwent repeated measurements of bonedensity at the lumbar spine, proximal femur and distal radius for up to 14 years. Individual rates of bone loss were calculated for the spine and hip; for radial trabecular bone, rates were calculated separately for two time periods, earlier and later after menopause. In the spine and radius, initially high rates of loss diminished with time after menopause. No positive correlations for bone loss were found between the three sites, suggesting that faster than average bone loss was specific to individual bones. High body mass index (BMI) was significantly protective against fast bone loss at the spine and radius; in the spine, each unit increase in BMI was associated with a ~5% reduction in the rate of bone loss. Of the other variables measured (maximum oxygen consumption,lean body mass, fat mass, mean psoas muscle area at the L3 level, hand grip strength as well as anthropometry) only bone densitometry was sufficiently predictive to help guidance on hormone replacement or other prophylactic therapy. The data suggest that the known relationship between excessive leanness and risk of osteoporosis and vertebral fracture after menopause might in part be due to fast postmenopausal bone loss. Because bulk of psoas muscle was associated with low spine loss rates, the data also support a role for applied muscular loading in local maintenance of bone density.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
J. S. Finkelstein, S. E. Brockwell, V. Mehta, G. A. Greendale, M. R. Sowers, B. Ettinger, J. C. Lo, J. M. Johnston, J. A. Cauley, M. E. Danielson, et al.
Bone Mineral Density Changes during the Menopause Transition in a Multiethnic Cohort of Women
J. Clin. Endocrinol. Metab., March 1, 2008; 93(3): 861 - 868.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
J. D. Knoke and E. Barrett-Connor
Weight Loss: A Determinant of Hip Bone Loss in Older Men and Women: The Rancho Bernardo Study
Am. J. Epidemiol., December 15, 2003; 158(12): 1132 - 1138.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.