Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Abraham, R. B.
Right arrow Articles by Perel, A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Abraham, R. B.
Right arrow Articles by Perel, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Q J Med 1997; 90: 13-18
© 1997 Association of Physicians

Malignant hyperthermia susceptibility: anaesthetic implications and risk stratification

R. Ben Abraham, A. Cahana, R.M. Krivosic-Horber1 and A. Perel

From the Department of Anesthesiology, Sheba Medical Center, Sackler School of Medicine, Tel-Aviv University Israel 1 Départment d'Anesthésie Réanimation Chirurgicale I, Hospital B, Centre Hospitalier Régional Universitaire 59037 Lille Cédex, France

Address correspondence to Dr A. Cahana, Department of Anesthesiology, Sheba Medical Center, Sackler School of Medicine, Tel-Aviv University, Israeli Center for MH Research and Treatment, Tel-Hashomer, Israel 52621

Received 11 June 1996 and in revised form 22 September 1996


  Abstract

Malignant hyperthermia (MH) is a rare autosomal dominant trait that predisposes individuals to great danger when exposed to certain anaesthetic triggering agents, such as potent volatile anaesthetics and succinylcholine. Sudden hypermetabolic reaction occurs in skeletal muscle, leading to hyperthermia and massive rhabdomyolysis. Precautions must be taken before the anaesthesia of MH-susceptible patients. No triggering agents should be administered, central body temperature and ETCO2 should be carefully monitored, and dantrolene must be immediately available. In addition, the anaesthesia machine should be carefully washed to remove traces of halogenated agents, and the use of fresh disposable anaesthetic circuits is recommended. Early diagnosis of the syndrome by alert, informed anaesthesiologists, and the immediate administration of dantrolene and other supportive measures, has reduced mortality. Patients with MH susceptibility should be instructed to alert the anaesthesiologist about their condition whenever anaesthesia is needed. Although people diagnosed with MH susceptibility should not change their lifestyle in general, military service is limited.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 PediatricsHome page
A. S. Hollander, R. C. Olney, P. R. Blackett, and B. A. Marshall
Fatal Malignant Hyperthermia-Like Syndrome With Rhabdomyolysis Complicating the Presentation of Diabetes Mellitus in Adolescent Males
Pediatrics, June 1, 2003; 111(6): 1447 - 1452.
[Abstract] [Full Text] [PDF]

Home page
 ptjournalHome page
J. K Kozack and D. L MacIntyre
Malignant Hyperthermia
Physical Therapy, March 1, 2001; 81(3): 945 - 951.
[Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
R. VANHOLDER, M. S. SEVER, E. EREK, and N. LAMEIRE
Rhabdomyolysis
J. Am. Soc. Nephrol., August 1, 2000; 11(8): 1553 - 1561.
[Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.