Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by POWELL, K.U.
Right arrow Articles by BROWN, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by POWELL, K.U.
Right arrow Articles by BROWN, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Q J Med 1994; 87: 283-290
© 1994 Association of Physicians

research-article

Helicobacter pylori eradication in patients with peptic ulcer disease: clinical consequences and financial implications

K.U. POWELL1, G.D. BELL1,, G.H. BOLTON4, S.M. BURRIDGE1, A.F. BOWDEN1, B. RAMEH1, L. HART1, P. BRADLEY7, C. HARRISON2, P.W. GANT5, J.E. TROWELL3 and C. BROWN6

1Departments of Medicine The Ipswich Hospital Ipswich, UK 2Departments of Medical Physics The Ipswich Hospital Ipswich, UK 3Departments of Histopathology The Ipswich Hospital Ipswich, UK 4Departments of Regional Drug Information Unit The Ipswich Hospital Ipswich, UK 5Departments of the PHLS The Ipswich Hospital Ipswich, UK 6Departments of Suffolk Medical Audit Advisory Group Facilitator The Ipswich Hospital Ipswich, UK 7Departments of Audit Office, The Ipswich Hospital Ipswich, UK

Address correspondence to Dr G.D. Bell, Department of Medicine, The Ipswich Hospital, Ipswich, Suffolk IP4 5PD

Received 24 January 1994 Accepted for publication 8 February 1994.

We assessed clinical consequences and financial implications of Helicobacter pylori eradication in 175 patients with peptic ulceration, of whom 106 had been free from H. pylori infection for a mean of 3.2 years, while 69 remained infected. We used quarterly questionnaires to examine consumption of ulcer-healing medication and antacids. In the 106 successfully treated patients, gastrointestinal haemorrhage as a complication of peptic ulcer complications during the 344 patient years after eradication (0.003 per patient year) was 18-fold lower than during the 912 patient years before eradication (0.056 per patient year). Of the H. pylori-negative patients, 12–18% used ulcer-healing medication during any one of the three-month periods of the survey, compared with 34–51 % of the patients with residual H. pylori infection. The average cost of the ulcer-healing drugs consumed by the H. pylori-negative patients was £30.59 during the 12 months of the survey, compared with £99.05 for H. pylori-positive patients. Consumption of antacids was also lower in the H. pylori-negative group. Successful eradication of H. pylori significantly reduced the annual cost of ulcer-healing drugs consumed by the patients with ulcer disease. Maintenance of ulcer remission following successful eradication of H. pylori also significantly reduced ulcer complications.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 GutHome page
J. LABENZ and P. MALFERTHEINER
Helicobacter pylori in gastro-oesophageal reflux disease: causal agent, independent or protective factor?
Gut, September 1, 1997; 41(3): 277 - 280.
[Full Text] [PDF]

Home page
 BMJHome page
P S Phull and M R Jacyna
Testing to check success of treatment to eradicate H pylori
BMJ, September 21, 1996; 313(7059): 752a - 752.
[Full Text]

Home page
 BMJHome page
T G Reilly and R P Walt
Routine retesting is necessary
BMJ, May 25, 1996; 312(7042): 1362 - 1362.
[Full Text]

Home page
 BMJHome page
K Bodger and R V Heatley
Testing to check success of treatment to eradicate H pylori
BMJ, May 25, 1996; 312(7042): 1361b - 1362.
[Full Text]

Home page
 BMJHome page
T Walley
Upper gastrointestinal endoscopy
BMJ, July 1, 1995; 311(6996): 57c - 58.
[Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.