Q J Med 1993; 86: 447-458
© 1993 Association of Physicians
research-article |
The BILAG index: a reliable and valid instrument for measuring clinical disease activity in systemic lupus erythematosus
From the ARC Epidemiology Research Unit, Stopford Building (University of Manchester) Oxford Road, Manchester M13 9PT
Received 15 February 1993 Accepted for publication 13 March 1993.
The British Isles Lupus Assessment Group (BILAG) index is a computerized index for measuring clinical disease activity in systemic lupus erythematosus (SLE), which was developed according to the principle of the physician's ‘intention to treat’. The index allocates separate alphabetic scores to each of eight organ-based systems; a total score is not calculated. This study demonstrated good between-rater reliability for the BILAG index for each organ-based system. There was no evidence of bias between observers. The BILAG index had good overall sensitivity (87%) and specificity (99%) when compared with the 'gold standard' criterion (starting or increasing disease-modifying therapy). There were high positive predictive values overall (80%), and for each organ-based system, with the exception of the neurological system.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S A Wright, F M O'Prey, M T McHenry, W J Leahey, A B Devine, E M Duffy, D G Johnston, M B Finch, A L Bell, and G E McVeigh A randomised interventional trial of {omega}-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus Ann Rheum Dis, June 1, 2008; 67(6): 841 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.A. Isenberg BILAG, SLEDAI, SIS, ECLAM, WAM, SLAM .... Thank you MAM Lupus, November 1, 2007; 16(11): 849 - 851. [PDF]
|
|
|
|
|
|
C. Mukhtyar, D. Boumpas, C. Gordon, W. Gross, D. Jayne, and R. Luqmani Why we need guidelines for clinical trials in vasculitis and systemic lupus erythematosus Ann Rheum Dis, May 1, 2007; 66(5): 569 - 570. [Full Text] [PDF]
|
|
|
|
|
|
M M A Fernando and D A Isenberg How to monitor SLE in routine clinical practice Ann Rheum Dis, April 1, 2005; 64(4): 524 - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. T. Ravirajan, L. Rowse, J. R. MacGowan, and D. A. Isenberg An analysis of clinical disease activity and nephritis-associated serum autoantibody profiles in patients with systemic lupus erythematosus: a cross-sectional study Rheumatology, December 1, 2001; 40(12): 1405 - 1412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. W. Miller, L. G. Rider, Y.-L. Chung, R. Cooper, K. Danko, V. Farewell, I. Lundberg, C. Morrison, L. Oakley, I. Oakley, et al. Proposed preliminary core set measures for disease outcome assessment in adult and juvenile idiopathic inflammatory myopathies Rheumatology, November 1, 2001; 40(11): 1262 - 1273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Bowman, S. Pillemer, R. Jonsson, K. Asmussen, C. Vitali, R. Manthorpe, and N. Sutcliffe Revisiting Sjogren's syndrome in the new millennium: perspectives on assessment and outcome measures. Report of a workshop held on 23 March 2000 at Oxford, UK Rheumatology, October 1, 2001; 40(10): 1180 - 1188. [Full Text] [PDF]
|
|
|
|
|
|
T. Stoll, Y. Kauer, S. Buchi, R. Klaghofer, T. Sensky, and P. M. Villiger Prediction of depression in systemic lupus erythematosus patients using SF-36 Mental Health scores Rheumatology, June 1, 2001; 40(6): 695 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D A Isenberg and C Gordon From BILAG to BLIPS--disease activity assessment in lupus past, present and future Lupus, November 1, 2000; 9(9): 651 - 654. [Abstract] [PDF]
|
|
|
|
|
|
J Thumboo, P-H Feng, C-H Soh, M-L Boey, S-t Thio, and K-Y Fong Validation of a Chinese version of the Medical Outcomes Study Family and Marital Functioning Measures in patients with SLE Lupus, November 1, 2000; 9(9): 702 - 707. [Abstract] [PDF]
|
|
|
|
|
|
T. Stoll, N. Sutcliffe, R. Klaghofer, and D. A Isenberg Do present damage and health perception in patients with systemic lupus erythematosus predict extent of future damage?: a prospective study Ann Rheum Dis, October 1, 2000; 59(10): 832 - 835. [Abstract] [Full Text]
|
|
|
|
 |
|
 P A Brogan and M J Dillon Personal practice: The use of immunosuppressive and cytotoxic drugs in non-malignant disease Arch. Dis. Child., September 1, 2000; 83(3): 259 - 264. [Full Text] [PDF]
|
|
|
|
|
|
S Buchi, P Villiger, Y Kauer, R Klaghofer, T Sensky, and T Stoll PRISM (Pictorial Representation of Illness and Self Measure) - a novel visual method to assess the global burden of illness in patients with systemic lupus erythematosus Lupus, June 1, 2000; 9(5): 368 - 373. [Abstract] [PDF]
|
|
|
|
|
|
D. Isenberg and R. Ramsey-Goldman Assessing patients with lupus: towards a drug responder index Rheumatology, November 1, 1999; 38(11): 1045 - 1049. [Full Text] [PDF]
|
|
|
|
|
|
M. H Liang, M. Corzillius, S.-C. Bae, P. Fortin, J. M Esdaile, and M. Abrahamowicz A conceptual framework for clinical trials in SLE and other multisystem diseases Lupus, October 1, 1999; 8(8): 570 - 580. [PDF]
|
|
|
|
|
|
D D Gladman and M. B Urowitz The SLICC/ACR damage index: progress report and experience in the field Lupus, October 1, 1999; 8(8): 632 - 637. [Abstract] [PDF]
|
|
|
|
|
|
R. Ramsey-Goldman and K. W Hayes Ensuring reliability of clinical assessments for SLE trials Lupus, October 1, 1999; 8(8): 671 - 676. [Abstract] [PDF]
|
|
|
|
|
|
S. M. Sultan, Y. Ioannou, and D. A. Isenberg A review of gastrointestinal manifestations of systemic lupus erythematosus Rheumatology, October 1, 1999; 38(10): 917 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.N. Purandare, A.C. Wagle, and S.R. Parker Psychiatric morbidity in patients with systemic lupus erythematosus QJM, May 1, 1999; 92(5): 283 - 286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D A Isenberg, C McClure, V Farewell, M Spellerberg, W Williams, G Cambridge, and F Stevenson Correlation of 9G4 idiotope with disease activity in patients with systemic lupus erythematosus Ann Rheum Dis, September 1, 1998; 57(9): 566 - 570. [Abstract] [Full Text]
|
|
|
|
|
|
Y Ikeda, T Fujimoto, M Ameno, H Shiiki, and K Dohi Relationship between lupus nephritis activity and the serum level of soluble VCAM-1 Lupus, June 1, 1998; 7(5): 347 - 354. [Abstract] [PDF]
|
|
|
|
|
|
D.A. Bell and R.J.T. Smeenk Clinical connections: assays and assessment Lupus, January 1, 1997; 6(3): 305 - 306. [PDF]
|
|
|
|
|
|
F. Erkeller-Yuksel, P. Lydyard, and D. Isenberg Lack of NK cells in lupus patients with renal involvement Lupus, January 1, 1997; 6(9): 708 - 712. [Abstract] [PDF]
|
|