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Q J Med 1993; 86: 739-742
© 1993 Association of Physicians

research-article

Mean platelet volume in diabetes mellitus

P. C. SHARPE and T. TRINICK

From the Department of Clinical Chemistry, Ulster Hospital Dundonald, Belfast, UK

Address correspondence to Dr P. C. Sharpe, Department of Clinical Chemistry, Ulster Hospital, Dundonald, Belfast BT16 ORH

Received 2 August 1993 Accepted for publication 19 August 1993.

We measured mean platelet volume (MPV) in patients with diabetes mellitus, compared with MPV in non-diabetic control subjects. Mean MPV was significantly increased in the diabetic subjects (8.9 ± 0.07 fL, mean ± SEM) compared with nondiabetic subjects (8.0 ± 0.05) (p < 0.001). Since platelet size is a determinant of platelet function, with larger platelets being more reactive per unit volume, we believe platelets may play a part in the micro- and macro-vascular complications of diabetes mellitus.


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