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Q J Med 1990; 74: 49-56
© 1990 Association of Physicians

other

Fat Absorption and Exocrine Pancreatic Function in Human Immunodeficiency Virus Infection

M. S. KAPEMBWA, S. C. FLEMING, G. E. GRIFFIN, K. CAUN*, A. J. PINCHING* and J. R. W. HARRIS{dagger}

Department of Communicable Diseases, St George's Hospital Medical School, Cranmer Terrace London, SW17 0RE *Department of Clinical Immunology Paddington, London W2 1PG {dagger}Department of Genito-urinary Medicine, St Mary's Hospital Medical School Paddington, London W2 1PG

Address correspondence to Dr M. S. Kapembwa

Accepted for publication 7 July 1989.

Exocrine pancreatic function and fat absorption were determined using a ‘tubeless’ test in 25 human immunodeficiency virus (HIV) antibody positive subjects (23 males, two females), CDC criteria groups II (four), III(one), and IV (20). In 12 fat absorption was poor but in only three of these were the results indicative of pancreatic insufficiency and in all three this was mild. In nine of the cases the results were compatible with small intestinal malabsorption.

Mild, but not severe, exocrine pancreatic insufficiency may occur in acquired immune deficiency syndrome; however fat malabsorption is more commonly associated with a small intestinal cause.


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