Q J Med 1988; 68: 629-636
© 1988 Association of Physicians
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Profile of Crescentic Glomerulonephritis in Natal - A Clinicopathological Assessment
Department of Medicine, Medical School, University of Natal Durban, Republic of South Africa *Department Anatomical Pathology, Medical School, University of Natal Durban, Republic of South Africa
Address correspondence to Dr K. B. Parag, Department of Medicine, University of Natal, Medical School, P.O. Box 17039, Congella, 4013, Republic of South Africa.
Accepted for publication 13 May 1988.
Crescentic glomerulonephritis is invariably associated with a fulminant syndrome of rapidly progressive renal failure which generally progresses to end-stage renal failure within weeks or months of onset. A widely differing aetiological background has been reported from Western countries. Work from the African continent is sparse. In a study from the province of Natal in South Africa between 1981 and 1987, 27 cases of crescentic nephritis were identified from a total of 458 patients who underwent renal biopsy at King Edward VIII and Addington hospitals. Post-streptococcal nephritis was the commonest aetiological factor (n=8). There were six black patients in this group. Nine patients were classified as idiopathic and of these five were black. Four patients (one black) had antiglomerular basement membrane disease. Of the 24 patients subjected to variable combinations of immunosuppression, antiplatelet agents, dialysis and plasmapheresis, 11 improved, observed over four months to four years. Oliguria and severe renal failure at presentation signified a poor prognosis.