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Q J Med 1988; 67: 309-317
© 1988 Association of Physicians

research-article

Cyclophosphamide-induced Liver Necrosis: A Possible Interaction with Azathioprine

S. SHAUNAK, J. M. MUNRO, K. WEINBREN, M. J. WALPORT and T. M. COX

Departments of Medicine and Histopathology, Hammersmith Hospital Du Cane Road, London, W12 OHS

Accepted for publication 24 November 1987.

SUMMARY

Cyclophosphamide is a valuable drug for the treatment of vasculit is and hepatic toxicity resulting from its use has been reported rarely. We describe four patients in whom cyclophosphamide was associated with liver injury when its administration had been preceded by azathioprine. Microscopy of hepatic biopsy material in three of these cases showed liver cell necrosis. In two of the patients, cyclophosphamide had been given previously without earlier azathioprine and hepatic damage had not been noted. An apparent interaction of cyclophosphamide with azathioprine to cause liver cell necrosis has important implications for the treatment of patients with vasculitis and related disorders.


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