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Q J Med 1988; 67: 299-308
© 1988 Association of Physicians

research-article

Family Screening in Medullary Thyroid Carcinoma Presenting Without a Family History

B. A. J. PONDER*,{dagger}, N. FINER{ddagger}, R. COFFEY§, C. L. HARMER*, M. MAISEY{ddagger}, M. G. ORMEROD{dagger}, M. E. PEMBREY§, M. A. PONDER{dagger}, P. ROSSWICK and S. SHALET**

*Royal Marsden Hospital Downs Road, Sutton, Surrey {dagger}Institute of Cancer Research Clifton Avenue, Sutton, Surrey {ddagger}Guy's Hospital London SE1 §Institute of Child Health Gulford Street, London WCl St George's Hospital Blackshaw Road, London SW17 OQT **Christie Hospital and Holt Radium Institute Wilmslow Road, Manchester M20 9BX

Accepted for publication 20 November 1987.

Systematic screening of the families of a series of 39 patients with apparently sporadic medullary thyroid carcinoma detected seven new cases in four families. A negative family history in a patients presenting with medullary thyroid carcinoma is not reliable in excluding familial disease, and family screening should be considered for new patients with medullary thyroid carcinoma.


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