Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by SMALL, M.
Right arrow Articles by FORBES, C. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SMALL, M.
Right arrow Articles by FORBES, C. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Q J Med 1987; 65: 1025-1031
© 1987 Association of Physicians

research-article

Thrombin and Plasmin Activity in Diabetes Mellitus and their Association with Glycaemic Control

M. SMALL, G. D. O. LOWE*, A. C. MacCUISH and C. D. FORBES*

Diabetic Unit, Roal Infirmary Glasgow G31 2ER *University Department of Medicine, Royal Infirmary Glasgow G31 2ER

Address correspondence to Dr M. Small, University Department of Medicine, Royal Infirmary, Glasgow G31 2ER.

Accepted for publication 30 July 1987.

Abnormalities of haemostasis are common in diabetes mellitus. As indicators of fibrinolysis and coagulation, plasmin and thrombin activity were assessed by assay of the fibrinogen peptide derivatives Bß15-42 and fibrinopeptide A respectively in 60 diabetic patients and 50 control subjects in a cross-sectional study. Glycosylated haemoglobin (HbA1) correlated with Bß15-42 (r=0.26, p<0.05) and fibrinopeptide A (r=0.30, p<0.05) in the diabetic patients suggesting that poor glycaemic control (i.e high HbA1 levels) was associated with depressed plasmin and enhanced thrombin activity. Compared to controls, fibrinopeptide A levels were increased in diabetics (p<) irrespective of sex or type of diabetes. Bß15-42 levels were normal in diabetic females but increased in diabetic men (p<0.001) possibly secondary to the activation of coagulation. These results suggest that in diabetes mellitus activation of coagulation is the dominant haemostatic abnormality and that better glycaemic control could influence in-vivo plasmin and thrombin activity favourably.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.