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Q J Med 1981; 50: 297-306
© 1981 Association of Physicians

research-article

The Nephrotic Syndrome in Ghana: Clinical and Pathological Aspects

D. ADU, Y. ANIM-ADDO, A. K. FOLI, J. M. BLANKSON, S. H. ANNOBIL, C. A. REINDROF and E. C. CHRISTIAN

From the Departments of Medicine and Therapeutics, Child Health and Pathology, Korle-Bu Hospital, University of Ghana Medical School P.O. Box 4236, Accra, Ghana

Correspondence to: Dr. D. Adu, Renal Unit. Guy's Hospital. London Bridge. London SE1 9RT.

Accepted for publication 4 March 1981.

Clinical and pathological features of the nephrotic syndrome were studied in 36 adults and 25 children in Ghana. No evidence was found to implicate Plasmodium malariae as a cause and in the majority of patients the aetiology was not identified.

Minimal change glomerulonephritis responsive to steroids was demonstrated in 14/25 children and 5/36 adults which was surprising as this lesion has been reported only rarely from tropical Africa. The other major histological lesions were focal segmental glomerulosclerosis (12/61), diffuse proliferative glomerulonephritis (11/61) and membranous glomerulonephritis (9/61).


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