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Q J Med 1977; 46: 1-32
© 1977 Association of Physicians

research-article

Systemic Lupus Erythematosus

A REVIEW OF 110 CASES WITH REFERENCE TO NEPHRITIS, THE NERVOUS SYSTEM, INFECTIONS, ASEPTIC NECROSIS AND PROGNOSIS1

PETER LEE2, MURRAY B. UROWITZ, ARTHUR A. M. BOOKMAN3, BARRY E. KOEHLER4, HUGH A. SMYTHE, DUNCAN A. GORDON5 and METRO A. OGRYZLO

2 Supported by a Canadian Arthritis and Rheumatism Society Fellowship and Rose Hellaby Medical Scholarship. Present address: Middlemore Hospital, Otahuhu, Auckland, N.Z.

3Present address: Toronto General Hospital Toronto, Ontario.

4Present address: The Port Arthur Clinic, Thunder Bay, Ontario.

5Present address: McMaster University, Hamilton, Ontario.

Accepted for publication 16 January 1976.

Observations made on 110 patients with SLE over a four and a half year period have been reviewed. The patients were seen at intervals of two months when, both clinical and serological findings were recorded, according to a set protocol. The results have been presented with particular reference to nephritis, neurological manifestations, infection, aseptic necrosis, mortality and predicted survival. Such studies have led to the identification of various prognostic factors in SLE, and assisted in providing better directed therapy.

The results indicate a milder form of SLE in the patients of this series when compared with previously published studies, and is more representative of the wide spectrum of disease severity seen in the general population.

1 From the University of Toronto Rheumatic Disease Unit, The Wellesley Hospital, 160 Wellesley Street East, Toronto, Ontario, Canada.


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