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Q J Med 1975; 44: 389-398
© 1975 Association of Physicians

research-article

Endotoxinaemia and the Pathogenesis of Acute Renal Failure

E. NIGEL WARDLE

Wellcome Research Laboratories, Royal Victoria Infirmary Newcastle upon Tyne NE1 4LP

Received 10 July 1974 A study has been made by Limulus assay of the incidence of endotoxinaemia in renal disease: positive results were found in 12/16 patients at the onset of acute renal failure. Results are supported by those of a platelet nitroblue tetrazolium reduction assay. In individual cases increased fibrinogen catabolism has been linked to substantial endotoxin levels. The assay can evaluate endotoxinaemia as a cause of acute renal failure and also detect secondary infection. Shwartzman equivalents appear to account for most cases of acute renal failure in man.


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