Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by LAM, S.-K.
Right arrow Articles by SIRCUS, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LAM, S.-K.
Right arrow Articles by SIRCUS, W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Q J Med 1975; 44: 369-387
© 1975 Association of Physicians

research-article

Studies on Duodenal Ulcer1

1. THE CLINICAL EVIDENCE FOE THE EXISTENCE OF TWO POPULATIONS

SHIU-KUM LAM and W. SIRCUS

Gastro-intestinal Unit, Western General Hospital Edinburgh

Received 4 June 1974 Secretory and clinical characteristics of 339 hospital patients with uncomplicated duodenal ulcers, 182 with pyloro-duodenal stenosis, 124 operated upon in Copenhagen by proximal vagotomy and 174 in whom bleeding or perforation was the reason for admission were studied. The results indicate that all duodenal ulcer subjects secrete more acid than normal, but that in approximately half of them acid secretion to maximal stimulation does not rise outwith the range of normal and most of these are of 0 blood group. These patients are classified as Type I duodenal ulcer. The character of acid hypersecretion beyond two standard deviations of the mean of the maximal acid output in normal subjects appears to be determined mainly by the possession of A, B and AB blood group: these hypersecreting ulcer patients are classified as Type II. The complications of perforation and bleeding and stenosis are linked mostly to the 0 group subjects and not to acid hypersecretion as such, but the strongest family prevalence is in the A, B, AB series and in them also the disease appears earlier.

A hypothesis is presented to explain the aetiology of the two types.

1Part of work to be presented for M.D. thesis, University of Hong Kong, 1974.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Psychosom. Med.Home page
S. Levenstein
The Very Model of a Modern Etiology: A Biopsychosocial View of Peptic Ulcer
Psychosom Med, March 1, 2000; 62(2): 176 - 185.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.