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Q J Med 1975; 44: 309-323
© 1975 Association of Physicians

research-article

Non-healing Granuloma and the Nervous System

J. M. ANDERSON, D. G. JAMIESON1 and J. M. JEFFERSON

Departments of Neurology, The Queen Elizabeth Hospital Edgbaston, Birmingham 1Dudley Road Hospital Birmingham

Received 24 July 1974 Three cases of non-healing granuloma with neurological complications are described. One case suffered from Stewart's form of the disease and two from Wegener's variety. The literature is extensively reviewed and the incidence and manner of neurological involvement in 374 cases is discussed.

We suggest a classification to indicate four forms of nervous system involvement. First, granulomatous lesions of the central nervous system. Second, vasculitis of the central nervous system. Third, vasculitis of the peripheral nervous system and fourth, infection of the central nervous system.

Of all cases 21 per cent had some form of neurological complication. Wegener's type showed more frequent neurological involvement than Stewart's, 26.5 and 12 per cent respectively. Infection of the central nervous system was limited to cases of the Stewart variety.


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