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Q J Med 1975; 44: 161-188
© 1975 Association of Physicians

research-article

The Haemolytic Uraemic Syndrome—A Family Study

M. J. FARR1, S. ROBERTS, A. R. MORLEY, P. J. DEWAR, D. F. ROBERTS and P. R. ULDALL

Newcastle Teaching Hospitals; the Department of Human Genetics, the University of Newcastle; and the Regional Blood Transfusion Service Newcastle upon Tyne

Received 24 July 1974 This study included patients, all relatives with the haemolytic uraemic syndrome, and 18 family members. The diagnosis was uncertain in one patient, probable in one other and definite in four patients. Three of these four comprised a father and two of his children.

Data are presented to emphasize the widespread nature of the disease. Other than hypertension, predisposing factors, and red cell and HL-A genetic markers, although sought, have not been found.

Management is discussed with special reference to the one surviving patient. Early bilateral nephrectomy may be life-saving.

1Present address: Department of Nephrology, Hull Royal Infirmary, North Humberside.


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