Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by TATTERSALL, R. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by TATTERSALL, R. B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Q J Med 1974; 43: 339-357
© 1974 Association of Physicians

research-article

Mild Familial Diabetes with Dominant Inheritance

R. B. TATTERSALL

Diabetic Department, King's College Hospital London, SE5 9RS

Received 15 September 1973 Three families have been described in which diabetes, although usually diagnosed in the teens or early 20s, is mild and does not progress to insulin dependence even over a period of 40 years. This syndrome seems to be inherited as a Mendelian dominant because (1) there is direct parent to child inheritance through at least three generations (2) the ratio of affected: unaffected children of diabetic parents is 1:1 and (3) almost all affected individuals have a diabetic parent. Complications are uncommon and mild. Seven out of 12 diabetics diagnosed under the age of 30 and having a mean duration of diabetes of 37 years did not have any retinopathy. No death from diabetes has ever been recorded in any of the families. In two families diabetes is associated with a low renal threshold for glucose. This syndrome is distinct from the more usual type of juvenile diabetes mellitus and provides evidence of the genetic heterogeneity of diabetes mellitus.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Arch. Dis. Child.Home page
S Ehtisham, A T Hattersley, D B Dunger, and T G Barrett
First UK survey of paediatric type 2 diabetes and MODY
Arch. Dis. Child., June 1, 2004; 89(6): 526 - 529.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C. Bingham, S. Ellard, A. J. Nicholls, C. A. Pennock, J. Allen, A. J. James, S. C. Satchell, M. B. Salzmann, and A. T. Hattersley
The Generalized Aminoaciduria Seen in Patients With Hepatocyte Nuclear Factor-1{alpha} Mutations Is a Feature of All Patients With Diabetes and Is Associated With Glucosuria
Diabetes, September 1, 2001; 50(9): 2047 - 2052.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M Gannon, M. Ray, K Van Zee, F Rausa, R. Costa, and C. Wright
Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function
Development, January 7, 2000; 127(13): 2883 - 2895.
[Abstract] [PDF]

Home page
 Arch. Dis. Child.Home page
K A Matyka, F Beards, M Appleton, S Ellard, A Hattersley, and D B Dunger
Genetic testing for maturity onset diabetes of the young in childhood hyperglycaemia
Arch. Dis. Child., June 1, 1998; 78(6): 552 - 554.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.