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Q J Med 1971; 40: 443-456
© 1971 Association of Physicians

research-article

Medullary Carcinoma of the Thyroid Gland

W. MILO KEYNES and A. S. TILL1

From the Department of Surgery Radcliffe Infirmary, Oxford

1Reprints from A. S. Till, Radcliffe Infirmary, Oxford

Received 5 March 1971 We report six patients with medullary carcinoma of the thyroid gland from a total of 92 with thyroid carcinoma seen in Oxford over an 11-year period. Our patients showed all the main features of this disease with the exception of mucosal neuromas. Medullary carcinoma, sporadic or familial, may be complicated by wide endocrine disorder and its associations with diarrhoea, flushing, calcitonin production, hyperparathyroidism, phaeochromocytoma, diabetes mellitus, and Cushing's syndrome are discussed. One patient died from glioblastoma multiforme and the possible relationship of this, the mucosal neuromas and the phaeochromocytomas to neuro-fibromatosis are considered.


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