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Q J Med 1971; 40: 435-442
© 1971 Association of Physicians


research-article

Polyneuritis Associated with Cytomegalovirus Infections

A REPORT FROM VARIOUS CENTRES

DR. B. HEYWORTH, DR. A. G. IRONSIDE, DR. R. LANGTON HEWER, DR. J. C. LEONARD, DR. R. T. MAYON-WHITE, DR. R. L. WARD, DR. S. WOODCOCK, DR. S. K. R. CLARKE, DR. S. D. GARDNER, DR. D. N. HUTCHINSON, DR. P. J. L. SEQUEIRA and DR. J. O'H. TOBIN

Monsall Hospital Manchester Frenchay Hospital Bristol Withingion Hospital Manchester Cardiff Royal Infirmary Royal Infirmary, Blackburn Royal Infirmary, Preston Public Health Laboratory Bristol Central Public Health Laboratory Colindale Public Health Laboratory Preston Central Serology Laboratory and Public Health Laboratory, Withington Hospital Manchester

Received 12 March 1971 Nine patients with polyneuritis associated with cytomegalovirus infection are described. The illness usually began with a mild respiratory infection followed by a severe polyneuritis affecting the cranial nerves, the limbs and, in four instances, the respiratory muscles. One patient died after a prolonged stormy illness characterized by panophthalmitis, diabetes mellitus, and presumed acute pancreatitis. Five of the patients had atypical mononuclear cells in the peripheral blood, but the Paul Bunnell test was negative. Isolation of the virus and/or a rising complement-fixation titre to cytomegalovirus was demonstrated in all cases except one.


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