Q J Med 1966; 35: 276-292
© 1966 Association of Physicians
research-article |
AUTONOMIC FAILURE WITH ORTHOSTATIC HYPOTENSION DUE TO INTERMEDIOLATERAL COLUMN DEGENERATION
A Report of Two Cases with Autopsies
Depts. of Neurology, Neuropathology and of the Regius Professor of Medicine, Radcliffe Infirmary Oxford
Received 24 July 1965 Two patients who had autonomio failure with orthostatic hypotension are described. Physiological studies indicated a preganghonic sympathetic lesion in the central nervous system.
Post-mortem examination in both cases showed severe nerve-cell loss in the intermediolateral columns (preganghonic sympathetic cells) of the spinal cord.
One case also showed the lesions of olivo-ponto-cerebellar atrophy. Both patients are considered to have been suffering from a primary neuronal degeneration.
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