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QJM Advance Access originally published online on December 5, 2008
QJM 2009 102(2):97-107; doi:10.1093/qjmed/hcn152
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© The Author 2008. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Myasthenic crisis

A. Chaudhuri1 and P.O. Behan2

1From the Essex Centre for Neurological Sciences and 2Division of Clinical Neurosciences, University of Glasgow, Scotland, UK

Address correspondence to Dr A. Chaudhuri, Consultant Neurologist & Clinical Lead in Neurology, Queen's Hospital, Rom Valley Way, Romford, Essex RM7 0AG. email: chaudhuria{at}gmail.com


  Abstract

Myasthenic crisis is a life-threatening medical emergency requiring early diagnosis and respiratory assistance. It can affect between one-fifth and one-third of all patients with generalized autoimmune myasthenia gravis. Myasthenic crisis is to be distinguished from other causes of acute neuromuscular paralysis which in most cases, can be achieved clinically. High dose corticosteroids in combination with plasma exchange or immunoglobulin are the cornerstone of treatment for this fully reversible cause of neuromuscular paralysis.


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