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QJM Advance Access originally published online on July 21, 2009
QJM 2009 102(10):743-745; doi:10.1093/qjmed/hcp092
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© The Author 2009. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

The enigma of pulmonary hypertension after splenectomy—does the megakaryocyte provide a clue?

J. Thachil

From the University of Liverpool, Liverpool, L7 8XP, UK

Address correspondence to Dr Jecko Thachil, Department of Haematology, University of Liverpool, Prescot Road, Liverpool, L7 8XP, UK. email: jeckothachil{at}yahoo.co.uk


  Abstract

Pulmonary hypertension is a common and debilitating condition which is increasingly being recognized in haematological patients. This is particularly so in haemolytic diseases like thalassaemia and myeloproliferative conditions like idiopathic myelofibrosis. Recently, splenectomy, which may be required for some of these conditions, have been linked to this complication although the exact pathophysiology is still not established. The manuscript explains the role of the less recognized ‘lung megakaryocytes’ in the development of this complication.


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