Skip Navigation


QJM Advance Access originally published online on May 15, 2007
QJM 2007 100(6):345-350; doi:10.1093/qjmed/hcm031
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
100/6/345    most recent
hcm031v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (2)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Donnelly, L.A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Donnelly, L.A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Adherence to insulin and its association with glycaemic control in patients with type 2 diabetes

L.A. Donnelly1, A.D. Morris2, J.M.M. Evans1 and for the DARTS/MEMO collaboration

From the 1Division of Community Health Sciences, University of Dundee, and 2Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK

Address correspondence to Ms L.A. Donnelly, Division of Community Health Sciences, Mackenzie Building, Kirsty Semple Way, Dundee DD2 4BF. email: l.y.donnelly{at}dundee.ac.uk

Received 24 May 2005 and in revised form 25 January 2007


  Abstract

Background: Good glycaemic control improves outcomes in patients with type 2 diabetes, but the extent to which this depends on adherence to insulin treatment is uncertain.

Aim: To investigate the association between adherence to insulin and glycaemic control in insulin-treated patients with type 2 diabetes.

Design: Observational records-based study.

Methods: We studied all patients with type 2 diabetes who were resident in Tayside, Scotland from 1 January 1995 to 30 September 2001, and who were treated with insulin. Adherence to insulin treatment was measured as the annual number of days of insulin coverage on the recommended dose, calculated from the amount of drug dispensed at community pharmacies and the recommended dose level for each patient. The association between glycaemic control (HbA1c), and adherence was determined, as was the influence of covariates, including age, sex, duration of diabetes and number of injections per day.

Results: A total of 1099 people were studied: 574 (52%) males and 525 (48%) females, mean ± SD age 62 ± 12 years, diabetes duration 10 ± 7 years. Median time in the study (time for which insulin was dispensed) was 1107 (range 366–2446) days. Insulin prescribed was 58.0 ± 33.3 IU/day and insulin collected from pharmacies was 53.6 ± 27.1 IU/day. Mean adherence to insulin was thus 70.6%±17.7%. Adherence to insulin (p = 0.0021), BMI (p = 0.0001) and diabetes duration (p = 0.0314) were all significant predictors of HbA1c.

Discussion: Adherence to insulin appears poor in these type 2 diabetes patients, and there was a significant relationship between adherence and long-term metabolic control.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am J Health Syst PharmHome page
J. Meece
Effect of insulin pen devices on the management of diabetes mellitus
Am. J. Health Syst. Pharm., June 1, 2008; 65(11): 1076 - 1082.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.