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QJM Advance Access originally published online on December 15, 2006
QJM 2007 100(1):19-27; doi:10.1093/qjmed/hcl132
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© The Author 2006. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

The role of skin-homing T cells in extrinsic atopic dermatitis

S.L. Seneviratne1, A.P. Black1, L. Jones1, A.S. Bailey1 and G.S. Ogg1,2

From the 1MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford and 2Department of Dermatology, Churchill Hospital, Oxford, UK

Address correspondence to Dr S.L. Seneviratne, Cutaneous Immunology Group, MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford OX3 9DS. email: suran200{at}yahoo.co.uk

Received 12 May 2006 and in revised form 10 August 2006


  Abstract

Background: T cells that express Cutaneous Lymphocyte-Associated antigen (CLA) have the potential of migrating to the skin, and are hypothesized to play a role in cutaneous atopic disease.

Aim: To investigate the immune phenotype and cytokine responses to Der p 1 stimulation of CLA+ T cells in extrinsic atopic dermatitis (EAD).

Design: In vitro testing, with controls.

Methods: Peripheral blood mononuclear cells (PBMC) were obtained from EAD patients (n = 27) and non-atopic healthy individuals (n = 22). Phenotypic analysis of naive, CLA+ and non-CLA+ memory/effector CD4+ and CD8+ T cells used markers of cell activation, differentiation, adhesion, apoptosis and chemokine receptor expression. Cytokine responses in these cells were studied following Der p 1 stimulation.

Results: CLA+ T cells from EAD patients expressed significantly higher levels of CD25, HLA-DR, CD38, CD71, CXCR1, CXCR2 and lower levels of bcl2, CCR5, CCR7, CXCR3, and CD62L (p < 0.05).

Discussion: In EAD patients, CLA+ T cells express increased levels of markers associated with activation, adhesion and apoptosis, show differences in the level of expression of differentiation markers and display a distinct chemokine receptor preference, compared with cells from healthy controls. These data suggest a significant role for CLA+ T cells in the pathogenesis of cutaneous atopic disease.


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